AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.
抑制蛋白酶體的(-)-表沒食子兒茶素沒食子酸酯衍生物
Summary
(-)-EGCG是最丰富的儿茶素，其被认为是化学预防及抗癌剂。然而，(-)-EGCG具有至少一个局限性：其生物利用度差。本发明提供了具有下列通式的化合物，其中R11、R12、R13、R21、R22、R2、R3和R4均各自独立地选自-H和C1-C10酰氧基；以及R5选自-H、C1-C10烷基、C2-C10烯基、C2-C10炔基、C3-C7环烷基、苯基、苯甲基和C3-C7环烯基，同时，最后提到的7个基团中的每一个都可用1到6个卤素原子的任意组合取代；R11、R12、R13、R21、R22、R2、R3和R4中至少有一个是-H，这些化合物被证实比其用作蛋白酶体抑制剂以减少肿瘤细胞生长的未被保护对应物更有效。
Industry
Disease Diagnostic/Treatment
Sub Group
Cancer/Tumor
Others
CHAN Tak-hang
LAM Wai-har
CHOW M.C. Larry
DOU Q. Ping (Wayne State Uni)
KUHN J. Deborah (Wayne State Uni)
KAZI Aslamuzzaman (Uni of S. Florida)
WAN Sheng Biao
LANDIS-PIWOWAR Kristin R. (Wayne State U
Country/Region
Mainland China
For more information, please click Here
