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Method of biosynthesizing tetrodotoxin

Summary

The present invention relates methods for the biosynthesis of tetrodotoxin (TTX) involving the steps of obtaining a culture possessing one or more of a Vibriospecies, such as through a seed culture, inoculating the culture and tissue extract from a textrodotoxin-bearing organism in a fermenter medium, and isolating and purifying tetrodotoxin from said fermenter, resulting in a yield of TTX of about 0.5 g TTX/L in about 3 to 5 days, such TTX being at least 90% pure.

Supplementary Information

Patent Number: US7977074B2
Application Number: US2007709657A
Inventor: Yu, Peter Hoi-fu | Yu, Chun Fai
Priority Date: 23 Feb 2007
Priority Number: US7977074B2
Application Date: 23 Feb 2007
Publication Date: 12 Jul 2011
IPC Current: C12P001718
US Class: 435119
Assignee Applicant: The Hong Kong Polytechnic University
Title: Method of biosynthesizing tetrodotoxin
Usefulness: Method of biosynthesizing tetrodotoxin
Summary: The method is used in biosynthesis of tetrodotoxin (claimed).
Novelty: Biosynthesis of tetrodotoxin involves simultaneously inoculating culture and growth tissue extract excised from textrodotoxin-bearing organism in fermenter with medium, and isolating and purifying tetrodotoxin from the medium

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Application No.

CN200880005935A

Others

YU Hoifu, Peter
YU Chun Fai

Country/Region

USA

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