大黃酸在治療纖維化病症和腫瘤的應用
Method of Using Rhein for Treating Fibrotic Conditions and Tumors
This invention introduces a new method of using an anthraquinone derivative or known as Rhein, for treating chronic pancreatitis. It is notably that Rhein or extracts from Polygonaceae (rhubarb) is a potential anti-fibrotic agent without giving any adverse effects in the animal study. Most importantly, this invention can suppress pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.
• Pure herbal extracts with minimal side effects
• Low toxicity
Used in pharmaceutical product for anti-inflammatory and/ or anti-cancer as well as consumed as a health supplement for specific clinical purpose.
The present inventionit relates to the method of usageing of an natural anthraquinone derivative, namely 9, 10-Dihyro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, also known as Rhein, as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatoryion, and fibrotic and tumorigenic pathologies in the pancreas of a subject.
Patent Number: CN103505448A
Application Number: CN201310217865A
Inventor: CHEN, Shi-lin | BIAN, Zhao-iang | CHEN, Xin-zi | QIN, Hong-yan | LV, Ai-ping | XU, Hong-xi | YANG, Da-jian | XIAO, Hai-tao | ZENG, Shao-hui
Priority Date: 4 Jun 2012
Priority Number: CN103505448A
Application Date: 3 Jun 2013
Publication Date: 15 Jan 2014
IPC Current: A61K0031192 | A61P000118 | A61P003500
Assignee Applicant: Hong Kong Baptist University
Title: Method of using rhein for treating fibrotic conditions and tumors
Usefulness: Method of using rhein for treating fibrotic conditions and tumors
Summary: For suppressing activation of pancreatic stellate cells and related fibrotic markers in fibrotic conditions or fibrotic related diseases, and for preventing or alleviating or treating pancreatic tumors or pancreatic tumors related diseases in a subject (i.e. a human). The fibrotic conditions comprising pancreatic fibrosis and fibrotic related diseases comprising chronic pancreatitis. The pancreatic tumors or pancreatic tumors related diseases comprising pancreatic ductal adenocarcinoma (claimed).
Disease Diagnostic/Treatment
Cancer/Tumor
2013.06.03
CN 201310217865.9
Filed
A61/BZ/Rhei/CN01
Hong Kong
