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The Usage of Treating Inflammation and Cancer for Natural Compound Garcimultiflorine E from Garcinia Esculenta Y.H. Li

Summary

This invention relates to use a natural compound from natural sources for its therapeutic uses. More particularly, it relates to a compound Garcimultiflorone E (GE), that is naturally occurring in the plant of Garcinia esculenta Y. H. Li has biological activity of potent anti-inflammation and anti-cancer effect.

Technology Benefits

The compound of the invention is useful for its anti-inflammatory and anti-tumor effects, and provides the candidate for anti-inflammatory and anti-cancer drugs.

Technology Application

The novel compound may have potential to be developed as anticancer drug.

Detailed Technology Description

Garcinia esculenta Y. H. Li belongs to Garcinia genus of plants. It is one of endemic plants in China, which mainly grew up in the valley and areas above 860-1650 m sea level, and has not been artificially cultivated. Matured fruit is edible.

Supplementary Information

Inventor: SHUM, Daisy Kwok Yan | IP, Mary Sau Man | CHAN, Chi Hang | LEUNG, Valeria On Yue
Priority Number: WO2011103774A1
IPC Current: A61K0031727 | A61K000912 | A61K000914 | A61P001100 | A61P001102
Assignee Applicant: The University of Hong Kong
Title: PHARMACEUTICAL COMPOSITION AND USE THEREOF IN MANUFACTURING MEDICAMENTS FOR TREATING RESPIRATORY DISEASES | COMPOSITION PHARMACEUTIQUE ET UTILISATION DE CELLE-CI DANS LA FABRICATION DE MÉDICAMENTS POUR TRAITER DES MALADIES RESPIRATOIRES
Usefulness: PHARMACEUTICAL COMPOSITION AND USE THEREOF IN MANUFACTURING MEDICAMENTS FOR TREATING RESPIRATORY DISEASES | COMPOSITION PHARMACEUTIQUE ET UTILISATION DE CELLE-CI DANS LA FABRICATION DE MÉDICAMENTS POUR TRAITER DES MALADIES RESPIRATOIRES
Summary: The composition is useful for treating a respiratory disease or disorder, such as one or more symptom of chronic respiratory inflammation and chronic respiratory inflammation including bronchiectasis, emphysema and chronic obstructive pulmonary disease, where the symptoms are prolonged or abnormal inflammation, permanently dilated bronchi, airflow limitation, chronic cough, sputum production, hemoptysis, dyspnea, air trapping, wheezing, chest pain or recurrent lung infection (all claimed). The composition is useful for treating e.g. vascular diseases including systemic lupus erythematosus, rheumatoid arthritis, scleroderma, dermatomyositis, mixed connective tissue disorder, vasculitis and sarcoid. Tests details are described but no results given.
Novelty: Composition, useful for treating respiratory disease e.g. chronic respiratory inflammation e.g. bronchiectasis and chronic obstructive pulmonary disease, comprises a agent to decrease neutrophil elastase activity in subject

Industry

Biomedical

Sub Category

Medical Composition

Application Date

2013.01.10

Application No.

10/1/2013 (US 61/750,887)

Others

Filed

ID No.

A61/BZ/Garc/US0P

Country/Region

Hong Kong