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Compounds, Methods of Preparation and Use thereof for Treating Cancer

Summary

It introduces two new compounds and their preparation methods as the potential anticancer drugs for treating cancer or tumor related diseases, especially for liver cells. This drug is originated from plants with anti-cancer activities as candidates for anticancer agents.

Technology Benefits

Low toxicity to other tissues in the body

Technology Application

Treat liver cancer cells or tumor related diseases

Detailed Technology Description

It presents two new anti-cancer compounds, namely compound A [1,2,5,6-tetrahydroxy-3-methoxy-4,7,8-tri(3-methylbut-2-enyl)-xanthone] and compound B [1,2,5,6-tetrahydroxy-2,3-dimethoxy-4,7,8-tri(3-methylbut-2-enyl)-xanthone], which are isolated from Garcinia nujiangensis and their preparation methods and use for treating cancer or tumor related diseases

Supplementary Information

Patent Number: US20130210906A1
Application Number: US13767885A
Inventor: XU, Hongxi | XIA, Zhengxiang | LAO, Yuanzhi | TAN, Hongsheng | BIAN, Zhaoxiang | YANG, Dajian | CHEN, Shilin | CHEN, Kaixian | CHAN, Albert Sun-Chi
Priority Date: 15 Feb 2012
Priority Number: US20130210906A1
Application Date: 15 Feb 2013
Publication Date: 15 Aug 2013
IPC Current: C07D031186
US Class: 514455 | 549392
Assignee Applicant: Hong Kong Baptist University
Title: COMPOUNDS, METHODS OF PREPARATION AND USE THEREOF FOR TREATING CANCER
Usefulness: COMPOUNDS, METHODS OF PREPARATION AND USE THEREOF FOR TREATING CANCER
Summary: The composition is useful for treating cancer or tumor related diseases (claimed). The ability of (Q) to treat cancer was tested in human HepG2 (liver hepatocellular cells) cancer cell line. The result showed that 1,2,5,6-tetrahydroxy-3-methoxy-4,7,8-tri(3-methylbut-2-enyl)-xanthone exhibited a percentage inhibition of 76.59705 at a concentration of 25 μ g/ml.
Novelty: Composition comprises xanthone derivatives or their mixtures, useful for treating cancer or tumor related diseases

Industry

Disease Diagnostic/Treatment

Sub Group

Cancer/Tumor

Application Date

2013.02.15

Application No.

US 13/767,885

Others

Published

ID No.

A61/BZ/Newc/US01

Country/Region

Hong Kong

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