Methods For The Identification Of Inhibitors Of Homocitrate Synthase As Antibiotics

The Present Inventors Have Discovered That Homocitrate Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Homocitrate Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Homocitrate Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Homocitrate Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.</Ptext>

Inventor: HUANG, Jiandong | JIN, Ye
Priority Number: WO2013000278A1
IPC Current: C12N001509 | C12N001511 | C12N0015113 | C12N0015115 | C12N001556 | C12N001563 | C12N001567 | C12N001572 | C12N001590
Assignee Applicant: The University of Hong Kong
Title: TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE | DISPOSITIF PORTABLE DE RÉGULATION À DOUBLE SENS D'UNE EXPRESSION GÉNÉTIQUE INDUITE PAR DES RIBORÉGULATEURS
Usefulness: TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE | DISPOSITIF PORTABLE DE RÉGULATION À DOUBLE SENS D'UNE EXPRESSION GÉNÉTIQUE INDUITE PAR DES RIBORÉGULATEURS
Summary: The gene expression control device is useful for studying gene function, and in medical field, preferably in gene therapy and biotechnology.
Novelty: Gene expression control device useful for studying gene function, comprises chloramphenical resistance gene linked to theophylline-specific aptamer fragment, lactose (lac) I gene, and native lacI-lacZ intergenic region

Biomedical

DNA/Gene Engineering

Hong Kong