Transgenic Plant-Derived Sirnas For Suppression Of Influenza Virus Propagation In Mammalian Cells
The Present Invention Provides Plant-Derived Agents To Interfere With The Nonstructural Ns1 Gene From The Influenza A Virus Subtype H1n1. More Particularly, The Sirnas That Exhibit Strong Inhibitory Activity Towards Ns1, Which Effectively Suppress Replication Of The Influenza Virus In Mammalian Cells. The Invention Further Provides Methods For Production Of Sirnas For The Suppression Of A Broad Range Of Influenza Viral Subtypes With Sequence Homologies.
Patent Number: US20060282921A1
Application Number: US2006402181A
Inventor: Lam, Eric | Poon, Lit | Zhou, Yuanxiang | Chye, Mee | Peiris, Joseph
Priority Date: 20 Apr 2005
Priority Number: US20060282921A1
Application Date: 10 Apr 2006
Publication Date: 14 Dec 2006
IPC Current: A01H000100 | A61K004800 | C07H002102 | C12N000504 | C12N001511 | C12N0015113 | C12N001582
US Class: 800288 | 435325 | 435419 | 514044A | 5360231 | 800294 | 514044
Title: Transgenic plant-derived siRNAs for suppression of influenza virus propagation in mammalian cells
Usefulness: Transgenic plant-derived siRNAs for suppression of influenza virus propagation in mammalian cells
Summary: The small interfering RNA is useful for suppressing viral propagation in mammalian cells infected with the influenza virus (claimed).
Novelty: Producing small interfering RNA useful for suppressing influenza virus propagation in mammalian cells, comprises producing transgenic plants transfected with a vector encoding an siRNA directed towards the H1N1 NS1 gene
Agriculture
Plant
Hong Kong
