Enzyme Activated Chemotherapy Of Liver Cancer
The Present Invention Provides Methods Of Screening For Anti-Cancer Drugs Based On The Activities Of Overexpressed Enzymes By The Cancer Cells To Convert Non-Toxic Compounds To Cytotoxic Drugs Which Can Specifically Kill These Cancer Cells. In Particular, The Present Invention Provides Methods Of Screening For Anti-Cancer Drugs Which Can Be Used To Treat Liver Cancer, Especially Hepatocellular Carcinoma. The Present Invention Also Provides Methods Of Treating Cancers, In Particular Liver Cancer, Especially Hepatocellular Carcinoma, By Administering To A Subject The Drugs Selected By The Screning Methods Of The Present Invention. In A Particular Embodiment, Naphthalene Or A Derivative Thereof Is Administered To A Subject. The Present Invention Further Provides Pharmaceutical Compositions For Treating Or Ameliorating Cancers As Well As Kits Containing Such Compositions.
Patent Number: AU200222943A
Application Number: AU200222943D
Inventor: CHUNG STEPHEN SUM MAN
Priority Date: 14 Jul 2000
Priority Number: AU200222943A
Application Date: 12 Jul 2001
Publication Date: 30 Jan 2002
IPC Current: A61K003100 | A61K003105 | C12Q000132 | G01N0033574
Assignee Applicant: The University of Hong Kong
Title: Enzyme activated chemotherapy of liver cancer
Usefulness: Enzyme activated chemotherapy of liver cancer
Summary: For screening anti-cancer drugs useful in the preparation of pharmaceutical composition, to treat or ameliorate liver cancer cells e.g. hepatocellular carcinoma cells (claimed). For determining anti-cancer activity of naphthalene and its derivatives.
Novelty: Screening for anti-cancer drug by contacting cancer cell overexpressing enzyme with drug in presence or absence of inhibitor and measuring and comparing substance level with cell death level in presence and absence of inhibitor
Disease Diagnostic/Treatment
Cancer/Tumor
Hong Kong
