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Uses of transgenic animals containing a type X collagen mutant

Summary

This invention provides an isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth. This invention provides a polypeptide encoded by the isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth. This invention also provides a polypeptide which comprise the portion of the mutated collagen X capable of regulating bone growth. This invention further provides a transgenic animal comprising an isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth.

Supplementary Information

Inventor: CHEAH KATHRYN | CHEUNG KENNETH
Priority Number: AT290596T
IPC Current: A01K0067027 | C07K001478 | C12N001512 | C12N001585 | A61K003800 | A61K004800
Assignee Applicant: The University of Hong Kong
Title: VERWENDUNG TRANSGENER TIERE, DIE EINE MUTATION DES COLLAGEN X ENTHALTEN
Usefulness: VERWENDUNG TRANSGENER TIERE, DIE EINE MUTATION DES COLLAGEN X ENTHALTEN
Novelty: Col10-13del DNA encoding mutated collagen X polypeptide, useful for treating a subject afflicted with dwarfism, osteoporosis and for improving speed of bone union after fracture

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Application No.

WO1999IB2129A

Country/Region

Hong Kong

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