Noninvasive Prenatal Testing
Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclaimpsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin .beta. subunit (hCG-.beta.), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control.
Inventor: Lo, Yuk Ming Dennis | Ng, Kai On | Tsui, Bo Yin | Chiu, Wai Kwun Rossa
Priority Number: US7235359B2
IPC Current: C12Q000168 | C07H002102 | C07H002104 | C12P001934
US Class: 43500617 | 435006 | 4350912
Assignee Applicant: The Chinese University of Hong Kong
Title: Method for diagnosing preeclampsia by detecting hCRH mRNA
Usefulness: Method for diagnosing preeclampsia by detecting hCRH mRNA
Summary: The method is useful for diagnosing, monitoring, or predicting preeclampsia, diagnosing, monitoring, or predicting pre-term labor, detecting presence of a fetus with trisomy 18 or 21 in a pregnant woman or detecting pregnancy in a woman (claimed). The method is also useful for diagnosing, monitoring, or predicting of a more severe clinical course than preeclampsia, such as eclampsia.
Disease Diagnostic/Treatment
Other Disease
02/MED/122
Inventor(s): Professor Dennis Y M Lo, Department of Chemical Pathology
Patent Status: US Patent Pending Chinese Patent Pending Australian Patent Pending Canadian Patent Pending Japanese Patent Pending European Patent Pending Hong Kong Patent Pending
Hong Kong
