A Marker for Prenatal Diagnosis and Monitoring
The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother’s blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods that distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
Patent Number: US7709194B2
Application Number: US2005144951A
Inventor: Lo, Yuk Ming Dennis | Chiu, Rossa Wai Kwun | Chim, Stephen Siu Chung | Tong, Yu-kwan | Ding, Chunming
Priority Date: 4 Jun 2004
Priority Number: US7709194B2
Application Date: 3 Jun 2005
Publication Date: 4 May 2010
IPC Current: C07H002104 | C12Q000168
US Class: 43500611 | 435006 | 43500617 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Chinese University of Hong Kong
Title: Marker for prenatal diagnosis and monitoring
Usefulness: Marker for prenatal diagnosis and monitoring
Summary: The methods an markers are useful for detecting or monitoring a pregnancy-associated disorder in a woman pregnant with a fetus, where the pregnancy-associated disorder is preeclampsia, preterm labor, hyperemesis gravidarum, ectopic pregnancy, a fetal chromosomal aneuploidy, trisomy 18, trisomy 21, trisomy 13, or intrauterine growth retardation.
Novelty: Detecting or monitoring a pregnancy-associated disorder, e.g. trisomy 18, comprises determining the methylation status of a maspin gene in the blood sample
Disease Diagnostic/Treatment
Other Disease
04/MED/169
Inventor(s): Professor Dennis Y M LO, Department of Chemical Pathology
Patent Status: US Patent Pending Australian Patent Pending European Patent Pending Canadian Patent Pending
Hong Kong
