Markers for prenatal diagnosis and monitoring
Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.
Inventor: Lo, Yuk-Ming Dennis | Chiu, Rossa Wai Kwun | Chim, Stephen Siu Chung | Tsui, Nancy Bo Yin
Priority Number: US7718367B2
IPC Current: C07H002104 | C12Q000168
US Class: 43500611 | 435006 | 43500617 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Chinese University of Hong Kong
Title: Markers for prenatal diagnosis and monitoring
Usefulness: Markers for prenatal diagnosis and monitoring
Summary: For diagnosing, monitoring or predicting preeclampsia in a pregnant woman who is during the first, second or third trimester of gestation, detecting the presence of fetus with trisomy 18 or 21 and for detecting pregnancy in a woman (claimed).
Novelty: Diagnosing, monitoring or predicting preeclampsia or fetus with Trisomy 18 or 21 in a pregnant woman, involves determining amount of RNA derived from specific genetic loci and comparing amount of RNA to standard control
Disease Diagnostic/Treatment
Other Disease
04/MED/175
Inventor(s): Professor Dennis Y M LO, Department of Chemical Pathology
Patent Status: Taiwanese Patent Pending US Patent Pending PCT Application Filed
Hong Kong
