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Engineering of Polymer-stabilized Drug Nanoparticles by Flash Nanoprecipitation

Summary

The invention provides an effective and pragmatic means for controlled production of polymer-stabilized drug nanoparticles with the desired particle size and surface properties for specific biological and pharmaceutical applications. At present there are no available technologies or approaches that can widely serve this purpose.

Supplementary Information

Inventor: Chow, Albert Hee Lum | Chow, Shing Fung | Zhang, Xin Ran | Wan, Ka Yee | Cheng, Kwok Kin | Baum, Lawrence William
Priority Number: US20130122058A1
IPC Current: A61K000914
US Class: 424400 | 51425407 | 514570 | 514678 | 977773 | 977906
Assignee Applicant: The Chinese University of Hong Kong
Title: ENGINEERING OF POLYMER-STABILIZED NANOPARTICLES FOR DRUGS WITH LOG P VALUES BELOW 6 BY CONTROLLED ANTISOLVENT PRECIPITATION
Usefulness: ENGINEERING OF POLYMER-STABILIZED NANOPARTICLES FOR DRUGS WITH LOG P VALUES BELOW 6 BY CONTROLLED ANTISOLVENT PRECIPITATION
Summary: For making nanoparticle; for drying the nanoparticle to yield a solid powder; and for delivering molecule having a Log P value of ≥ 3 is a drug, preferably itraconazole, Ibuprofen, or curcumin (claimed).
Novelty: Nanoparticle useful for delivering drug e.g. Ibuprofen, comprises molecule, amphiphilic diblock copolymer or surfactant, and hydrophilic polymer

Industry

Biomedical

Sub Group

Medical Composition

Application No.

11/MED/421

Others

Inventor(s): Professor Albert Chow and Professor Larry BAUM, School of Pharmacy Licensing Status: Available

Country/Region

Hong Kong

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