F-Cyclo - Carbene-catalysed aryl hydrogenation to cyclohexanes with fluorine substituents
- 總結
- An efficient manufacturing process or fluorinated cyclohexane derivatives and related heterocycles
- 技術優勢
- Selective synthesis
High yields
All-cis orientation
Access for pharmaceutically interesting substances
Different substituents possible
- 技術應用
- Fluorinated cyclohexane derivatives are used as a raw material for pharmaceutically active substances and have been chemically accessible only in low yields until now . Such compounds play a major role in the pharmaceutical or agrochemical field due to the polarity of the C-F bond with concomitant steric similarity to C-H bonds and other effects
- 詳細技術說明
- An efficient manufacturing process for fluorinated cyclohexane derivatives and related heterocycles is obtained by hydrogenation of fluorinated aromatics with the help of rhodium carbene catalysts. Thus, fluorinated all-cis cyclohexane derivatives are readily prepared by direct hydrogenation of the fluoroaromatics.
- 合作類型
- Licensing
- 申請日期
- 27/03/2017 00:00:00
- 申請號碼
- WO2018EP54554 20180223
- 分類
- - international:
C07C17/354; C07C23/10; C07C69/75
- cooperative:
C07B31/00; C07C17/354; C07C41/20; C07C67/303; C07F15/0086; C07F5/04; C07F7/0803; C07F7/1804; C07B2200/09; C07C2601/14; C07J1/0059; C07J15/00 more
- 其他
- Patent application
- ID號碼
- 4980
- 國家/地區
- 德國
欲了解更多信息，請點擊 這裡
