New fluorogenic substrates for monoamine oxidases
- 技術優勢
- -- The technology highlights enzyme activity with greater sensitivity than other fluorogenic substrates because it emits at a range farther away from regions of autofluorescence.
- 技術應用
- -- The technology can be used for real-time monitoring of MAO activity (e.g., in neurotransmission) in intact neural tissue.-- The technology can be used for drug screening.
- 詳細技術說明
- The technology is an efficient and selective fluorogenic reporter substrate for MAO-A and MAO-B. This substrate is based upon 6-aminocoumarin modified with an aminoethyl side chain. The technology relies upon a redox switch based on a sequence of oxi...
- *Abstract
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None
- *Inquiry
- Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- M05-005
- *Principal Investigation
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- *Publications
- Design of Optical Switches as Metabolic Indicators: New Fluorogenic Probes for Monoamine Oxidases (MAO A and B), J. Am. Chem. Soc., Vol. 127, No. 13, pp. 4544-4545, 2005.
- *Web Links
- Patent pending: US20100035279
- 國家/地區
- 美國
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