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New fluorogenic substrates for monoamine oxidases

Technology Benefits
-- The technology highlights enzyme activity with greater sensitivity than other fluorogenic substrates because it emits at a range farther away from regions of autofluorescence.
Technology Application
-- The technology can be used for real-time monitoring of MAO activity (e.g., in neurotransmission) in intact neural tissue.-- The technology can be used for drug screening.
Detailed Technology Description
The technology is an efficient and selective fluorogenic reporter substrate for MAO-A and MAO-B. This substrate is based upon 6-aminocoumarin modified with an aminoethyl side chain. The technology relies upon a redox switch based on a sequence of oxi...
*Abstract
None
*Inquiry
Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
*IR
M05-005
*Principal Investigator
*Publications
Design of Optical Switches as Metabolic Indicators: New Fluorogenic Probes for Monoamine Oxidases (MAO A and B), J. Am. Chem. Soc., Vol. 127, No. 13, pp. 4544-4545, 2005.
*Web Links
Patent pending: US20100035279
Country/Region
USA

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