Novel High Efficiency Library-identified CNS-tropic AAV Vectors
- 詳細技術說明
- Newly designed recombinant AAV capsids with greater efficiency for CNS delivery than AAV9, the natural variant currently known as having the highest CNS transduction efficiency. These new AAV capsids
- *Abstract
-
Newly designed recombinant AAV capsids with greater efficiency for CNS delivery than AAV9, the natural variant currently known as having the highest CNS transduction efficiency. These new AAV capsids, B1-B4, show considerably lower off-target effects in the liver when compared to AAV9. Additionally, each of these AAV capsids show selectively higher efficiency for specific peripheral tissues (e.g. pancreas, smooth muscle, heart, adipocyte).
- *IP Issue Date
- None
- *IP Type
- Other Patent
- 國家
- Not Available
- 申請號碼
- None
- 國家/地區
- 美國
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