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Novel High Efficiency Library-identified CNS-tropic AAV Vectors

Detailed Technology Description: Newly designed recombinant AAV capsids with greater efficiency for CNS delivery than AAV9, the natural variant currently known as having the highest CNS transduction efficiency. These new AAV capsids

Countries: Not Available

Application No.: None

*Abstract: Newly designed recombinant AAV capsids with greater efficiency for CNS delivery than AAV9, the natural variant currently known as having the highest CNS transduction efficiency. These new AAV capsids, B1-B4, show considerably lower off-target effects in the liver when compared to AAV9. Additionally, each of these AAV capsids show selectively higher efficiency for specific peripheral tissues (e.g. pancreas, smooth muscle, heart, adipocyte).

*IP Issue Date: None

*IP Type: Other Patent

Country/Region: USA

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