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Three-Dimensional Porous Membrane that Mimics in vitro Epithelia

详细技术说明

The invention describes a method to fabricate porous polymer membranes that are shaped in 3D to form tall villi.

*Abstract

This microporous, polymeric membrane can be used flat or made into highly controlled microscale three-dimensionally shaped surfaces to simulate living membrane, such as villi. This membrane can also be integrated into multi-organ cell culture systems and “body-on-a-chip” devices.

 

This invention offers several notable improvements over similar membrane technologies.

 

Potential Commercial Applications

• In vitro models of human barrier tissues to simulate drug absorption and uptake
• Drug screeningIntegration with microfluidic and/or multi-organ cell culture systems
• Integration with non-microfluidic systems
• Cancer and other disease research

 

*Licensing

Jeff Fearnjcf55@cornell.edu607-254-4502

其他

• Patent issued in the U.S. 9,821,309
• Esch,M.B., Sung, J.H., Yang, J. Yu, J., March, J.C., Shuler, M.L. “On Chip PorousPolymer Membranes for Integration of Gastrointestinal Tract Epithelium withMicrofluidic ‘Body-on-a-Chip’ Devices”, Biomedical Microdevices, 2012, 14 (5),895-906. DOI 10.1007/s10544-012-9669-0.

 

国家/地区

美国