亚洲知识产权资讯网为知识产权业界提供一个一站式网上交易平台，协助业界发掘知识产权贸易商机，并与环球知识产权业界建立联系。无论你是知识产权拥有者正在出售您的知识产权，或是制造商需要购买技术以提高操作效能，又或是知识产权配套服务供应商，你将会从本网站发掘到有用的知识产权贸易资讯。

返回搜索结果

Nanoparticles for Drug Delivery, Tissue Targeting and Imaging Analysis

技术优势: Nanoparticle synthesis does not require pre-purification of reagents or detergent solubilization of components Allows for the production of membrane proteins that can be captured as isolated as soluble entities Utilizes entirely cell-free processes and technologies Telo-NLP nanoparticles can execute site specific attachment/immobilization though telodendrimer-based chemistry, which means that no antibodies or fusion protein tags are required to immobilize the nanoparticles on any desired surface Telo-NLP nanoparticles use non-antigenic material The final size and monodispersity of the nanoparticles can be selected for by varying the ratio of telodendrimer-to-lipid concentrations, or varying the telodendrimers themselves Multiple types of telodendrimers can be used in synthesis to allow for multifaceted functions, including tumor targeting or drug delivery Novel size and stable compound

技术应用: Supporting membrane proteins, small molecules, hydrophobic drugs and other moieties for targeting specific tissues and tumors for drug treatment and drug developmentRapid design and production of in vivo targeting, imaging and therapeutic delivery of biologically active molecules though direct surface conjugation to the telodendrimersEffective drug delivery system that can further increase drug efficacy

详细技术说明: Nanolipoprotein particles (NLPs) are nanoscale patches of lipid bilayer stabilized by peripheral scaffold. NLPs have distinct advantages over currently used membrane systems in terms of particle size and consistency. Currently, the greatest use of NLPs has been the stabilization and characterization of membrane proteins. Researchers at the University of California, Davis have developed a novel nanoparticle. When used to synthesize NLPs, these nanoparticles allow for NLPs to be used in in vivo drug delivery, tissue/cancer targeting, and imaging analysis. Additionally this technology also provides important information about the structure and function of membrane-bound proteins in water soluble particles that mimic the hydrophobic cell membrane. The combination of lipoprotein, lipids, and telodendrimers creates highly homogenous nanoparticles throughout the NLP, which has not been achieved by other means. Researchers at the University of California, Davis have developed a novel nanoparticle. When used to synthesize NLPs, these nanoparticles allow for NLPs to be used in in vivo drug delivery, tissue/cancer targeting, and imaging analysis. Additionally this technology also provides important information about the structure and function of membrane-bound proteins in water soluble particles that mimic the hydrophobic cell membrane. The combination of lipoprotein, lipids, and telodendrimers creates highly homogenous nanoparticles throughout the NLP, which has not been achieved by other means.

*Abstract: Nanoparticles made of lipoproteins, lipids, and telodendrimers for in vivo drug delivery, tissue/cancer targeting, and imaging analysis.

*IP Issue Date: May 9, 2017

*Principal Investigation: Name: Matthew Coleman
Department:

Name: Wei He
Department:

Name: Paul Henderson
Department:

Name: Kit Lam
Department:

Name: Juntao Luo
Department:

Name: Matthew Coleman
Department:

Name: R. Holland Cheng
Department:

Name: Li Xing
Department:

申请号码: 9644038

其他

Additional Technologies by these Inventors

Tech ID/UC Case

24124/2010-279-0

Related Cases

2010-279-0

国家/地区: 美国

欲了解更多信息，请点击这里