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Nanoparticles for Drug Delivery, Tissue Targeting and Imaging Analysis

Technology Benefits: Nanoparticle synthesis does not require pre-purification of reagents or detergent solubilization of components Allows for the production of membrane proteins that can be captured as isolated as soluble entities Utilizes entirely cell-free processes and technologies Telo-NLP nanoparticles can execute site specific attachment/immobilization though telodendrimer-based chemistry, which means that no antibodies or fusion protein tags are required to immobilize the nanoparticles on any desired surface Telo-NLP nanoparticles use non-antigenic material The final size and monodispersity of the nanoparticles can be selected for by varying the ratio of telodendrimer-to-lipid concentrations, or varying the telodendrimers themselves Multiple types of telodendrimers can be used in synthesis to allow for multifaceted functions, including tumor targeting or drug delivery Novel size and stable compound

Technology Application: Supporting membrane proteins, small molecules, hydrophobic drugs and other moieties for targeting specific tissues and tumors for drug treatment and drug developmentRapid design and production of in vivo targeting, imaging and therapeutic delivery of biologically active molecules though direct surface conjugation to the telodendrimersEffective drug delivery system that can further increase drug efficacy

Detailed Technology Description: Nanolipoprotein particles (NLPs) are nanoscale patches of lipid bilayer stabilized by peripheral scaffold. NLPs have distinct advantages over currently used membrane systems in terms of particle size and consistency. Currently, the greatest use of NLPs has been the stabilization and characterization of membrane proteins. Researchers at the University of California, Davis have developed a novel nanoparticle. When used to synthesize NLPs, these nanoparticles allow for NLPs to be used in in vivo drug delivery, tissue/cancer targeting, and imaging analysis. Additionally this technology also provides important information about the structure and function of membrane-bound proteins in water soluble particles that mimic the hydrophobic cell membrane. The combination of lipoprotein, lipids, and telodendrimers creates highly homogenous nanoparticles throughout the NLP, which has not been achieved by other means. Researchers at the University of California, Davis have developed a novel nanoparticle. When used to synthesize NLPs, these nanoparticles allow for NLPs to be used in in vivo drug delivery, tissue/cancer targeting, and imaging analysis. Additionally this technology also provides important information about the structure and function of membrane-bound proteins in water soluble particles that mimic the hydrophobic cell membrane. The combination of lipoprotein, lipids, and telodendrimers creates highly homogenous nanoparticles throughout the NLP, which has not been achieved by other means.

Application No.: 9644038

Others

Additional Technologies by these Inventors

Tech ID/UC Case

24124/2010-279-0

Related Cases

2010-279-0

*Abstract: Nanoparticles made of lipoproteins, lipids, and telodendrimers for in vivo drug delivery, tissue/cancer targeting, and imaging analysis.

*IP Issue Date: May 9, 2017

*Principal Investigator: Name: Matthew Coleman
Department:

Name: Wei He
Department:

Name: Paul Henderson
Department:

Name: Kit Lam
Department:

Name: Juntao Luo
Department:

Name: Matthew Coleman
Department:

Name: R. Holland Cheng
Department:

Name: Li Xing
Department:

Country/Region: USA

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