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Initiators For Block-Copolypeptide Synthesis

技术优势: These initiators: Eliminate chain-transfer and chain-termination side reactions from these polymerizations resulting in narrow molecular-weight distributions, molecular-weight control, and the ability to prepare copolymers of defined sequence and composition; Are readily prepared in a single step from commercially-available materials; Enable the preparation of large quantities of high molecular-weight polypeptides (molar masses up to 500,000 g/mol) with well-defined architectures; Are complementary to solid-phase peptide-synthesis techniques routinely used by scientists for the preparation of small oligopeptide sequences (generally less than 30 amino acid residues).

技术应用: The features of these initiators allow the preparation of complex biomaterials which have potential applications in biology, chemistry, physics and materials engineering. More specifically, these biomaterials can be used in areas such as: Drug delivery; Tissue engineering; "Smart" hydrogels (environmentally responsive organic materials); Organic or inorganic biomimetic composites such as artificial bone or high performance coatings; Models for protein folding or assembly.

详细技术说明: A scientist at the University of California has developed a series of initiators for the polymerization of NCAs into block copolypeptides. These initiators eliminate chain-transfer and chain-termination side reactions from the polymerization so that block copolymers of amino acids can be prepared.

*Abstract: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions which prevent the formation of block copolymers. The mechanisms of NCA polymerization have been under intensive study to find a method for enhancing control over chain growth in these reactions. These investigations have been severely hindered by the complexity of the polymerizations, which can proceed through multiple pathways.

*Principal Investigation: Name: Scott Curtin
Department:

Name: Timothy Deming
Department:

Name: Scott Seidel
Department:

Name: Jungyeon Hwang
Department:

Name: Michael Wyrsta
Department:

Name: Andrew Nowak
Department:

Name: Miaoer Yu
Department:

附加资料: Patent Number: US6680365B1
Application Number: US1999272109A
Inventor: Deming, Timothy J.
Priority Date: 19 Mar 1998
Priority Number: US6680365B1
Application Date: 19 Mar 1999
Publication Date: 20 Jan 2004
IPC Current: C07K000108
US Class: 530333 | 530338 | 556001 | 556045 | 556136 | 556137 | 556138
Assignee Applicant: The Regents of the University of California
Title: Methods and compositions for controlled polypeptide synthesis
Usefulness: Methods and compositions for controlled polypeptide synthesis
Summary: For the preparation of amino acid based polymers, which are useful in biochemical engineering, drug delivery and selective separation and in peptide synthesis.
Novelty: Preparation of block copolypeptide useful in polypeptide synthesis involves reacting amino acid N-carboxyanhydride monomer with initiator complex and reacting another N-carboxyanhydride monomer with a polyamino acid chain

其他

Additional Technologies by these Inventors

Tech ID/UC Case

10111/1998-109-0

Related Cases

1998-109-0

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