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Initiators For Block-Copolypeptide Synthesis

Technology Benefits

These initiators: Eliminate chain-transfer and chain-termination side reactions from these polymerizations resulting in narrow molecular-weight distributions, molecular-weight control, and the ability to prepare copolymers of defined sequence and composition; Are readily prepared in a single step from commercially-available materials; Enable the preparation of large quantities of high molecular-weight polypeptides (molar masses up to 500,000 g/mol) with well-defined architectures; Are complementary to solid-phase peptide-synthesis techniques routinely used by scientists for the preparation of small oligopeptide sequences (generally less than 30 amino acid residues).

Technology Application

The features of these initiators allow the preparation of complex biomaterials which have potential applications in biology, chemistry, physics and materials engineering. More specifically, these biomaterials can be used in areas such as: Drug delivery; Tissue engineering; "Smart" hydrogels (environmentally responsive organic materials); Organic or inorganic biomimetic composites such as artificial bone or high performance coatings; Models for protein folding or assembly.

Detailed Technology Description

A scientist at the University of California has developed a series of initiators for the polymerization of NCAs into block copolypeptides. These initiators eliminate chain-transfer and chain-termination side reactions from the polymerization so that block copolymers of amino acids can be prepared.

Supplementary Information

Patent Number: US6680365B1
Application Number: US1999272109A
Inventor: Deming, Timothy J.
Priority Date: 19 Mar 1998
Priority Number: US6680365B1
Application Date: 19 Mar 1999
Publication Date: 20 Jan 2004
IPC Current: C07K000108
US Class: 530333 | 530338 | 556001 | 556045 | 556136 | 556137 | 556138
Assignee Applicant: The Regents of the University of California
Title: Methods and compositions for controlled polypeptide synthesis
Usefulness: Methods and compositions for controlled polypeptide synthesis
Summary: For the preparation of amino acid based polymers, which are useful in biochemical engineering, drug delivery and selective separation and in peptide synthesis.
Novelty: Preparation of block copolypeptide useful in polypeptide synthesis involves reacting amino acid N-carboxyanhydride monomer with initiator complex and reacting another N-carboxyanhydride monomer with a polyamino acid chain

Industry

Chemical/Material

Sub Category

Chemical/Material Application

Application No.

7968519

Others

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• UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools
• Functionalized Polypeptides by Alkylation of Thioether Groups via Ring Opening Reactions
• Preparation Of Functional Homocysteine Residues In Polypeptides And Peptides
• Compositions Of Polyion Complex Polypeptide Hydrogels

Tech ID/UC Case

10111/1998-109-0

Related Cases

1998-109-0

*Abstract

Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions which prevent the formation of block copolymers. The mechanisms of NCA polymerization have been under intensive study to find a method for enhancing control over chain growth in these reactions. These investigations have been severely hindered by the complexity of the polymerizations, which can proceed through multiple pathways.

*IP Issue Date

Jun 28, 2011

*Principal Investigator

Name: Scott Curtin

Department:

Name: Timothy Deming

Department:

Name: Scott Seidel

Department:

Name: Jungyeon Hwang

Department:

Name: Michael Wyrsta

Department:

Name: Andrew Nowak

Department:

Name: Miaoer Yu

Department:

Country/Region

USA