Compounds for use in chelation therapy - 1788
- *Abstract
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Overview
A chelator, or chelating agent, is a polydentate ligand that bonds to more than one coordination site of a metal ion. Chelating agents have long been known in the art to be useful in chemical analysis, in environmental remediation and in medicine. In chelation therapy, a chelating agent is employed to bind a poisonous metal agent such as mercury, arsenic, iron, lead or aluminum in order to displace the ion from biological ligands such as proteins and convert the metal ion into a less toxic form that can be excreted without further interaction with the body.
Invention
UK researchers are developing numerous compounds for use in chelation therapy. Novel chelating agents were designed, and then immobilized, tethered chelators were created by linking those chelating agents to immobilized supports. These immobilized chelators are used to remove trivalent metals such as Al3+ from aqueous systems in situ, in vivo, and in vitro.
Applications
- chelation therpay
Advantages
- removes both trivalent and tetravalent metal ions from aqueous solutions
- removes trivalent ions in situ, in vivo, and in vitro
IP Status
U.S. Patent No. 7,932,326
U.S. Patent No. 9,139,456
- Country/Region
- USA
