Antifungal and Antiparasitic Indoloquinoline Derivatives
- Detailed Technology Description
- The tetracyclic structure of indolo[3,2-b]quinolines, also referred to as quindoline (1) constitutes as important structural moiety in the literature because of its effect on numerous biological functions.
- *Abstract
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An indoloquinoline wherein th equarternary N-5 atom is a straight C(1-5) chain, a branched c(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chanin substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substitutedterminally by a cycloalkyl or aromatic ring; the 10 position is N-R₁₀, O,S,S=O, CH₂, or C=O, where R₁₀ is a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted termianally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring. In one embodiment the quarternary N-5 atom in-CH₃ and the 10 position is N-(CH₂)₅-Ph.
- Country/Region
- USA
