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Masking Apertures Enabling Automation and Solution Exchange in Sessile Droplet Lipid Bilayers

Technology Benefits

Easily arrayable Automatable Scalable Compatible

Technology Application

Integration for high-throughput testing Scientific studies of ion channels Pharmaceutical screening

Detailed Technology Description

Researchers at UCLA have developed a novel device for creating artificial lipid bilayer members by utilizing an aperture that masks the monolayer contact area, enabling formation of highly consistent bilayer areas and significantly reducing their variation with changes in relative position of the monolayers. The device design is scalable and compatible with SBS standard instrumentation and automation technology, enabling its use for rapid and parallel automated measurements of ion channels for large scale scientific studies and pharmaceutical screening.

Supplementary Information

Patent Number: MY147461A
Application Number: MY2009PI1673A
Inventor: SULAIMAN AUS M | AL-TALIB SAHAR ABDUL AZIZ MAGEED | ARIS NOR AZRISHAHRIL | ABBAS MAZLAN BIN
Priority Date: 24 Apr 2009
Priority Number: MY147461A
Application Date: 24 Apr 2009
Publication Date: 14 Dec 2012
IPC Current: H04W003600
Assignee Applicant: MIMOS BERHAD
Title: A METHOD AND SYSTEM OF HANDLING OFF FOR MOBILE NODE MOBILITY
Usefulness: A METHOD AND SYSTEM OF HANDLING OFF FOR MOBILE NODE MOBILITY

Industry

Chemical/Material

Sub Category

Chemical/Material Application

Application No.

9150598

Others

State Of Development

Researchers have created a working prototype and have demonstrated its functionality and repeatability.

Background

The reconstitution of ion channels and transmembrane proteins in planar lipid bilayer membranes allow for functionality testing in highly controlled environments. Recent work with lipid bilayers formed from mechanically joined monolayers has shown their potential for wider technological applications, including automation and parallelization. Although fully automated formation and measurement of functional planar lipid bilayers is currently possible using the contacting monolayer technique; automated formation of such 'droplet' lipid bilayers having consistent and repeatable sizes, however, has not been demonstrated. Further, bilayer areas are highly sensitive to variations in mechanical positions and the bilayers themselves cannot withstand significant perfusion of adjacent solutions.

Additional Technologies by these Inventors

• Hydrogel-Supported Lipid Membranes

Tech ID/UC Case

22616/2012-141-0

Related Cases

2012-141-0

*Abstract

UCLA researchers in the Department of Bioengineering have created a scalable platform that allows for the formation and measurement of consistent droplet lipid bilayers featuring compatibility with high-throughput automation technology and SBS standard instrumentation.

*Applications

• Integration for high-throughput testing
• Scientific studies of ion channels
• Pharmaceutical screening

*IP Issue Date

Oct 6, 2015

*Principal Investigator

Name: Shiva Portonovo

Department:

Name: Jason Poulos

Department:

Name: Jacob Schmidt

Department:

Country/Region

USA