A Feeder Cell Engineered to Propagate NK Cells or T Cells Resistant to Suppression by Members of the TGF-β Family
- Detailed Technology Description
- None
- Countries
- Not Available
- Application No.
- None
- *Abstract
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NaturalKiller (NK) cells or T cells that are resistant to TGF-β have been shown tohave improved anti-cancer activity against TGF-β -secreting tumors. However,current methods for generating TGF-B resistant cell lines require large amountsof costly clinical-grade TGF-β. Researchers at Nationwide Children’s Hospital havedeveloped a novel feeder cell line that delivers a reproducible amount of TGF-Bsignal to natural killer (NK) cells during expansion, generating TGF-βresistant NK cells. This technology provides a simple, cheap, and reproducibleprocess for generating TGF-β resistant cells for research or therapeuticapplications.
- *Inquiry
- Andrew Corris The Research Institute at Nationwide Children’s HospitalOffice of Technology Commercialization700 Children’s DriveColumbus, OH 43205T: (614) 355-1604 F: (614) 722-2716Andrew.Corris@nationwidechildrens.org
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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