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Method for rapid high-resolution imaging of large biological samples

Summary
This technology employs a variation of Light Sheet Microscopy called Light Sheet Theta (LS-theta) microscopy to image large biological samples without sacrificing imaging depth or quality.
Technology Benefits
Improved image quality Better imaging depth Accommodates multiple modes of planar imagingDe-synchronized detection allows for greater imaging speedAdaptive correction of parameters allows for high-quality imaging across the entire sampleEliminates limits on lateral dimensions without sacrificing imaging depth and speed
Technology Application
3D imaging of living tissuesImaging of thick slices of human tissues, such as brain slices or other organsImaging of intact brains of large animals, including rat and primateLive imaging for functional activity in mouse brain3D cell culture imagingImaging embryo developmentVolumetric imaging of small organismsOptogenetic applications
Detailed Technology Description
None
*Abstract
None
*Inquiry
Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
*IR
CU17099
*Principal Investigator
*Publications
Tech Ventures Reference:IR CU17099Licensing Contact: Beth Kauderer
Country/Region
USA

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