A Diagnostic Test for Monitoring of Lupus Nephritis
- Technology Application
- Discrimination between patients with activeLN and active non-LNMonitoring disease activity and response totherapyAccurately stratifying patients with regardsto extent and nature of renal injury without in vivo interventionInforming long-term prognosis
- Detailed Technology Description
- Validatedurine test for the diagnosis, monitoring and prognosis of Lupus Nephritis
- *Abstract
-
Lupus nephritis (LN)is a major predictor of poor prognosis of the patients with systemic lupuserythematosus (SLE). The incident rate for SLE varies from 7.4 to 159.4 casesper 100,000 people. Since renal involvement is a major complication of thedisease current diagnostic of LN includes renal biopsy to confirm disease andto establish histopathological classification of the underlying renal lesion.Identification of histopathological differences is critical for establishingappropriate therapeutic interventions and for prognostic outcomes for LN. Nosuitable biomarkers that predict early response to therapy or forecast renalflares have been identified.
The urinarytest was developed (60 active LN patients, 25 active non-LN SLE patients and 24healthy controls) and validated (for numbers see figure legend) by researchersfrom the University Health Network in collaboration with the researcher fromthe Ontario Institute for Cancer Research. Eight (8) urinary proteins aredifferentially expressed in patients with proliferative and non-proliferativeor chronic lesions on renal biopsy.
Thevalidation study for some of urinary proteins presented in the figure below.Thescattered plots demonstrate the normalized concentration of adiponectin, plasminogenactivator inhibitor-1 (PAI-1), interleukin 15 (IL-15), platelet factor 4 (PF4)and metalloproteinase-1 (TIMP-1). The study included SLE patients with active non-LN(ANLN, n=16, closed circles), active LN (ALN, n=33, closed triangles) and inremission (n=30, open triangles).
- *Principal Investigator
-
Dr. Joan Wither, University HealthNetwork (lead researcher)
- *Publications
- Landolt-Marticorena C, Prokopec SD, Morrison S, Noamani B, Bonilla D, and Wither J. A discrete cluster of urinary biomarkers discriminates between active Systemic Lupus Erythematosus patients with and without glomerulonephritis. Arthritis Research and Therapy (2016) 18:2118
- Country/Region
- USA
