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Pharmacological Prevention of Chronic Post-surgical Pain

Detailed Technology Description

InventionFaculty at the University of Arizona developed a novel therapeutic that targets the activation of a signaling pathway to treat both acute post-surgical pain and itch and prevent the transition to chronic pain. The invention contains a topical cream treatment at the incision site with either a commonly used, safe drug and/or a natural product that acts via the same pathway.Dysregulated protein translation regulation pathways that underlie persistent pain states can be negatively regulated by activation of a particular signaling factor. The aim is to establish this signaling factor as a mechanism for the alleviation of post-surgical, and possibly other persistent pain. The inventors use two drugs that possess different mechanisms of this signaling activation to demonstrate a shared endpoint. A combination use of oral drug and topical cream containing the natural product may have wide applications for chronic post-surgical pain prevention.BackgroundChronic pain following surgery is a major clinical issue. Between 10 to 50% of patient who have surgery develop chronic pain, which can be debilitating in 2 to 10% of these cases. Currently available therapeutics given for acute post-surgical pain do not always prevent the transition to chronic pain. Therefore, treatments that target the molecular pathology promoting post-surgical pain, particularly chronic pain, are needed.AdvantagesTherapeutic targets a signaling factor that has not been used to treat painHas great potential to treat both acute and chronic post-surgical painThe two compounds include a widely prescribed pharmaceutical product and the other being a natural productApplicationsTreatment of acute post-surgical pain and itchPrevention of transition to chronic painInventorTheodore J. PriceContactPaul R. Eynott PhDLicensing Manager, Tech Launch ArizonaPaulE@tla.arizona.eduRefer to Technology UA13-118

*Abstract

None

*Principal Investigator

Name: Theodore Price, Associate Professor

Department:

Name: Gregory Dussor, Assistant Professor

Department: Pharmacology

Name: Dipti Tillu, Graduate Associate

Department: Pharmacology

Name: Bo Lian, Student Group D

Department: Pharmaceutical Sciences

Country/Region

USA