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UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

Technology Benefits

Hydrogel version is thermoresponsive – an injectable liquid at room temp, solid at body temp Hydrogel possesses nano and microscale network to allow cell attachment and proliferation Able to load vesicles and hydrogels with hydrophilic and/or hydrophobic payloads Potential low toxicity and biodegradability due to synthetic polymerized peptide building block Vesicles can penetrate cell membranes to intracellularly deliver payloads Stable at high temperature (up to 80°C in water) and can be engineered to various sizes (50 to 1000nm) Inexpensive starting material and process chemistry used to synthesize peptidic polymers

Detailed Technology Description

With the increasing elderly population, the wound management market has been greatly affected, primarily due to the increase incidents of skin ulcers and surgical procedures. The wound management market has begun investing heavily in advanced dressing technologies as a means to address the rise in healthcare costs.These advanced dressing technologies include materials to deliver cells to the wound site; materials to deliver proteins, such as collagen, to the wound; and materials to act as artificial skin or as skin replacement. Many of these advanced materials are based on nanoscale gels and vesicles as a means to adhere to the wound at the cellular level. These nanoscale systems offer the promise of minimizing toxicity, maximizing bioavailability, and potentially reducing scarring.

Application No.

20170296672

Others

Other Information

References: UCLA Cases 1998-072, 2001-307, 2007-014, 2008-767, 2012-598, 2013-315, 2015-124, 2015-452, 2015-612

Deming Group: http://deming.seas.ucla.edu/

For further information on this innovation, contact:

Rick Clark
Technology Transfer Officer, Life Sciences
Rick.clark@research.ucla.edu
310-794-0204

 

Additional Technologies by these Inventors

• Initiators For Block-Copolypeptide Synthesis
• Nanoparticle Assembled Hollow Spheres
• UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Particles and Gels for Use in the Industrial Biomaterials Market
• Functionalized Polypeptides by Alkylation of Thioether Groups via Ring Opening Reactions
• Preparation Of Functional Homocysteine Residues In Polypeptides And Peptides
• Compositions Of Polyion Complex Polypeptide Hydrogels

Tech ID/UC Case

25501/2015-124-0

Related Cases

2015-124-0

*Abstract

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

*IP Issue Date

Oct 19, 2017

*Principal Investigator

Name: Timothy Deming

Department:

Name: Michael Sofroniew

Department:

Name: Shanshan Zhang

Department:

Country/Region

USA