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Anti-Progesterone in Breast Cancer Chemoprevention
Technology Application
Treatment of BRCA1 mediated breast cancer
Detailed Technology Description
Treatment with anti-progesterone, mifepristone, prevents tumorigenesis in mice carrying mutated Brca1/p53 alleles. Anti-progesterone pellet containing 30mg/60 days constant release mifepristone (RU486), or placebo pellet was implanted into twelve 3- and two 4- month-old mice. Mice were monitored weekly for tumor formation. All control mice or placebo pellet treated mice developed palpable tumors. In the RU486 treated group no palpable tumors were detected.The invention is published in Science 1 December 2006 314: 1467-1470
Application No.
9517240
Others
Tech ID/UC Case 18780/2006-560-0 Related Cases 2006-560-0
Country/Region
USA
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