Dynamic Microfluidic Assays
- Technology Benefits
- High separation timescale and resolution: allows for real-time modulation and readout of biomolecule reaction processesDynamic analysis of chemical and structural nature of switching processesShort assay times compared to state-of-the-art alternativesSmall sample required for detectable resultsCompatible with range of molecule separation methods and read-out detectors
- Technology Application
- Design, characterization and engineering of biological probesMicrofluidic western blotAnalytical and diagnostic assaysDynamic assessment of reaction kinetics, interactions, dissociations of given interactionsEngineering of biomaterials, for example biomimetic smart materials
- Detailed Technology Description
- None
- Supplementary Information
- Inventor: FAKHRU'L-RAZI AHMADUN | MOHD HALIM SHAH ISMAIL | THOMAS CHOONG SHEAN YAW
Priority Number: MY140158A
IPC Current: C11B000102
Assignee Applicant: Universiti Putra Malaysia
Title: AN IMPROVED CONTINUOUS STERILIZATION PROCESS FOR PALM OIL MILL PROCESSING
Usefulness: AN IMPROVED CONTINUOUS STERILIZATION PROCESS FOR PALM OIL MILL PROCESSING
- Industry
- Agriculture
- Sub Category
- Food
- Application No.
- 20140158537
- Others
-
Publication
Additional Technologies by these Inventors
- Automated Microfluidic Device for Analyte Detection
- Microfluidic Enzyme Separation And Assay By Pore Limit Electrophoresis
- Microfluidic Chip For Rapid Multi-Analyte Detection
- Protein Renaturation Microfluidic Devices
- Microfluidic Blotting Device
- Automated Two-Dimensional Electrophoresis In Microfluidic Chamber
- Single-Cell Isoelectric Focusing and pH Gradient Arrays
Tech ID/UC Case
22826/2013-035-0
Related Cases
2013-035-0
- *Abstract
-
Many biomolecules can exist in more than one stable state or configuration and can switch reversibly between them. Molecular switching may occur spontaneously or in response to an external stimulus, such as change in pH, light, or temperature. Molecular switches have numerous applications in life and engineering sciences, including selective drug administration or molecular electronics, and understanding their switching properties is essential for the development of these applications.
Scientists at UC Berkeley have designed a microfluidic device that dynamically measures molecular switching in real-time, using microfluidic molecular separation techniques. For example, the device has been used to better understand the photophysical properties of the widely used biological probe, green fluorescent protein (GFP). In addition to assaying biomolecule switching, this device can be used to separate and identify proteins in a biological sample, and thus be used as a microfluidic western blot that requires only small sample volumes.
- *Applications
-
- *IP Issue Date
- Jun 12, 2014
- *Principal Investigator
-
Name: Amy Herr
Department:
Name: Alex Hughes
Department:
Name: Augusto Tentori
Department:
- Country/Region
- USA
