Osteoconductive Drug-eluting Scaffold for Bone Regeneration
- Detailed Technology Description
- None
- Others
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- *Abstract
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This invention consists of an osteoconductive material which can be used simultaneously as a scaffold and as a delivery device for growth factors to regenerate bone. The osteoconductive material consists of hollow hydroxyapatite (HA) microspheres with a mesoporous shell wall which are loaded with a growth factor such as bone morphogenetic protein-2 (BMP-2) known to stimulate bone regeneration. The growth factor-loaded HA microspheres can be implanted as individual microspheres, three-dimensional (3D) constructs composed of interconnected hollow HA microspheres, or as composites composed of individual hollow HA microspheres infiltrated with an organic phase (such as a biodegradable hydrogel or polymer) or dispersed in the organic phase. When loaded with BMP-2, implants composed of individual hollow HA microspheres regenerated bone more than 2 times faster than similar implants without growth factor or bioactive glass implants (scaffolds or particles) without growth factor.
- *Principal Investigator
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Name: MOHAMED RAHAMAN, Professor
Department:
Name: Hailuo Fu
Department:
Name: Delbert Day, Curators' Professor Emeritus
Department:
Name: Yongxing Liu, Asst Research Professor
Department:
- Country/Region
- USA
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