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NEW CLASS OF CHIRAL SELECTORS FOR ENANTIOMERIC SEPARATIONS

Detailed Technology Description: None

Supplementary Information: Patent Number: US6669842B1
Application Number: US1999396974A
Inventor: Armstrong, Daniel
Priority Date: 22 Feb 1994
Priority Number: US6669842B1
Application Date: 7 Sep 1999
Publication Date: 30 Dec 2003
IPC Current: B01J0020281 | B01D001508 | B01J002026 | B01J0020291 | B01J002032 | C07B005700 | G01N002514 | G01N0027447 | G01N003088 | G01N003002
US Class: 2101982 | 2105021 | 210635 | 210656
Assignee Applicant: Curators of the University of Missourilumbia
Title: Macrocyclic antibiotics as separation agents
Usefulness: Macrocyclic antibiotics as separation agents
Novelty: Sepg. enantiomers from fluid soln. comprises treating fluid with macrocyclic antibiotic and recovering sepd. enantiomers, esp. useful in chromatography and electrophoresis

Industry: Chemical/Material

Sub Category: Organic Chemical

Others

*Abstract: Abstract of US Patent 7,008,533 - Macrocyclic antibiotics as separation agents: Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography. Also see patents: 5,626,757; 5,874,005; 5,964,996; and 6,669,842.Non-Confidential Abstract of Invention: A new class of molecules (comprising a large variety of structural types) is shown to be highly effective as chiral selectors for the separation, purification, and quantitation of enantiomeric compounds. These new chiral selectors can be used as bonded or coated stationary phases in HPLC, GC, TLC, and CE. Also they can be dissolved in free solution in order to achieve separations in HPLC, CE, and TLC.

*Principal Investigator: Name: DANIEL ARMSTRONG
Department:

Country/Region: USA

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