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Single chain antibodies directed to pancreatic beta cells

Detailed Technology Description: The intellectual property relates to beta- or alpha-cell specific single chain antibodies (SCAs) that enable the specific and non-invasive transport of a selected therapeutic agent to pancreatic islet - or α-cells.

*Abstract: In one aspect, fusion proteins comprising a single chain antibodies (SCA) specific for pancreatic beta- cells and a NEMO binding domain (NBD) [SCA B1-NBD fusion protein] protects islets against the deleterious effects of IL-1beta in vitro, diabetogenic agents in vivo, and enables nearly complete protection from developing diabetes in multiple low dose streptozotocin (MLDS) treated mice. Taken together, the SCA B1-NBD chimera affords highly specific, targeted therapy to beta-cells, and provides a novel, non-invasive strategy of SCA-mediated beta-cell specific delivery with potential to prevent cell death.

Country/Region: USA

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