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Neuropiln 1 (Nrp1) Modulation for Immune System Control (SJ-13-0012)

Detailed Technology Description: Description Boosting the ability of regulatory T cells by blocking an effective anti-tumor immune response led to the elimination or dramatic reduction of melanoma by the immune system in mice, without causing the autoimmune and inflammatory problems often associated with current cancer-treatment efforts that target immune regulators. The mechanism is built around two proteins. One, semaphorin-4a (Sema4a), is carried on the surface of various immune cells that can spark inflammation. The other, neuropilin-1 (Nrp1), is carried on the surface of regulatory T cells.

*Abstract: Granted Patents or Published Applications
Related Scientific References 'Regulatory T cell stability is maintained by a neuropilin-1:semaphorin-4a axis' is published on Nature.com: http://dx.doi.org/10.1038/nature12428. (Abstracts are available to everyone, full text only to subscribers; relevant references are cited in the paper and can be provided on request)

Country/Region: USA

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