A systems biology method to predict oncogenes and perturbation targets on a cellular level
- Summary
- Andrea Califano, Ph.D.
- Technology Benefits
- Considers multiple levels of cellular relationships dysregulated during cancer progression Predicts which molecular interactions, as opposed to which genes, are dysregulated in a particular tumor phenotypeConsistently outperformed existing methods such as differential expression analysis in identifying key oncogenes and secondary effector genes.Patent Information:Patent Pending (WO/2009/092024)Tech Ventures Reference: IR 2339
- Technology Application
- Prediction of diagnostic markers and/or therapeutic targets for various cancers and other diseasesDevelopment of personalized diagnostic and therapeutic cancer solutionsResearch tool to generate hypotheses about network interactions in any cellular contextGenerating interactome databases for various cell types
- Detailed Technology Description
- Andrea Califano, Ph.D.
- *Abstract
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None
- *Inquiry
- Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- 2339
- *Principal Investigator
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- *Publications
- Wang K, Saito M, Bisikirska BC, Alvarez MJ, Lim WK, Rajbhandari P, Shen Q, Nemenman I, Basso K, Margolin AA, Klein U, Dalla-Favera R, Califano A. "Genome-Wide identification of post-translational modulators of transcription actor activity in human B cells" Nat Biotechnol. 2009 Sept;27(9):829-839.
- *Web Links
- WIPO: WO/2009/092024
- Country/Region
- USA
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