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Ultrasound technique for opening the blood-brain barrier to treat neurological disorders

Summary: Elisa E. Konofagou, Ph.D.

Technology Benefits: Does not require an MRI to confirm opening of the blood-brain barrierShows obstructions in real time so the opening can be adjustedTranscranial, noninvasive information gatheringPatent information:Patent Pending (WO/2012/162664)Tech Ventures Reference: IR 2965

Technology Application: Real-time monitoring of blood-brain barrier opening with microbubbles by ultrasoundCould allow for the delivery of more kinds of drugs to the brainCould be used in other tissues such as muscle, liver, and tumor tissues

Detailed Technology Description: Elisa E. Konofagou, Ph.D.

*Abstract: None

*Inquiry: Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2965

*Principal Investigator

*Publications: F. Marquet, T. Teichert, S.-Y. Wu, Y.-S. Tung, M. Downs, S. Wang, C. Chen, V. Ferrera, E.E. Konofagou. "Real-Time, Transcranial Monitoring of Safe Blood-Brain Barrier Opening in Non-Human Primates" PLOS One. Feb 5, 2014, 9(2), e84310.

Country/Region: USA

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