Microfluidic bead-based PCR microchip for detection, isolation, and amplification of nucleic acids
- Summary
- Qaio Lin, Ph.D.Milan Stojanovic, Ph.D.
- Technology Benefits
- Cost effective, accelerated pathogen and aptamer identification system amenable to diverse laboratory settingsMicrochip includes integrated microheater and a temperature sensor for effective, rapid control of thermal cycling temperaturesSingle, integrated device for aptamer and pathogen identification, isolation, and amplificationElimination of complex flow control elements and elaborate diagnostic equipmentEradicated cross contamination between device functional chambersImproved detection sensitivity, rendering the technology useful for identification of low concentrations of biomolecules Patent information:Patent Issued (WO/2013/119260) Tech Ventures Reference: IR M11-110, CU13132, CU12184, CU12181, CU12179, CU12097
- Technology Application
- Expedient and sensitive detection of pathogenic organismsEfficient and accurate aptamer identificationSingle nucleotide polymorphism (SNP) detection platformBiomolecule amplification and isolationAssay integration for biochemical research Biosensor microfluidic device. Biosensors for clinical diagnostics and drug delivery
- Detailed Technology Description
- Qaio Lin, Ph.D.Milan Stojanovic, Ph.D.
- *Abstract
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None
- *Inquiry
- Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- CU12184
- *Principal Investigator
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- *Publications
- Hilton, J.P., Nguyen, T., Barbu, M., Pei, R., Stojanovic, M., Lin, Q. "Pathogen Detection Using Microfluidic Bead-Based Polymerase Chain Reaction" Transducers 2011. 2011 June 190-193.Hilton, J.P., Nguyen, T., Barbu, M., Pei, R., Stojanovic, M., Lin, Q. " Bead-Based Polymerase Chain Reaction on a Microchip" Microfluidics and Nanofluidics. 2012 November. 13 (5) 749-760.J. Zhu, T. Nguyen, R. Pei, M. Stojanovic, Q. Lin. Specific capture and temperature-mediated release of cells in an aptamer-based microfluidic device. Lab Chip, 2012, Vol. 12, pp. 3504-3513
- Country/Region
- USA
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