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Thiol-based surface chemistry allows for single molecule florescence studies of biomolecules

Technology Benefits: • Increased sensitivity in fluorescence microscopy studies.• Efficient single-molecule observations.• Greater accuracy in determining excitation events.• Eliminates necessity for performing background calibration experiments.Patent information: US 61/554,305 A1

Technology Application: • Single Molecule DNA sequencing• Bio-sensors• Protein studies • Enzyme-activity essays could be replaced or improved (ELISA)• Investigations of cellular metabolism• Nanoelectronics

Detailed Technology Description: Tech Ventures Reference: IR CU12055 Gold-based zero-mode waveguides are functionalized using thiol surface chemistry, enabling biocompatibility for single molecule fluorescence applications.Single molecule studies ...

*Abstract: None

*Inquiry: Jullian JonesColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: CU12055

*Principal Investigator

*Publications: M. Palma, J. Abramson, A. A. Gorodetsky, E.Penzo, R.L. Gonzalez, M.P. Sheetz, C. Nuckolls, J.Hone and S. J. Wind. "Selective biomolecular nanoarrays for parallel single-molecule investigations," Journal of the American Chemical Society, Vol. 133, Issue 20, May 2011, pp. 7656-7659.

Country/Region: USA

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