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Rapid, high-resolution, and depth-resolved non-invasive optical tissue imaging

Technology Benefits: Imaging at high frame-rate Can image up to depths greater than 2 mm 100-200 micron resolution Multi-wavelength imaging of absorption, fluorescence and flow contrast Imaging and simultaneous measurements of living dynamic systems Can generate 3D (depth-resolved) images of surveyed region

Technology Application: Clinical imaging (diagnostic/evaluative, treatment response) Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. "Depth-resolved optical imaging of transmural electrical propagation in perfused heart", Optics Express, 15 (26), 17827-17841, 2007.Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss GW, Skoch J, Bacskai J, Dale A. M, Boas D. A. "Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation", NeuroImage, 35(1): 89-104 (2007)

Detailed Technology Description: Laminar optical tomography (LOT) is a technique which allows non-contact depth-resolved optical imaging of living tissues to depths of >2 mm with 100-200 micron resolution. LOT allows the simultaneous quantification of absorption (and hence oxy- a...

*Abstract: None

*Inquiry: Donna SeeColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2155

*Principal Investigator

*Publications: Implementation:• Yuan B, Burgess SA, Iranmahboob AK, Bouchard MB, Lehrer N, Bordier C, Hillman E. M. C, "A System for rapid, simultaneous, high resolution, depth-resolved fluorescence and absorption optical imaging", Rev. Sci. Instrum. 80, 043706 (2009).• Hillman E. M. C, Burgess S.A. "Sub-millimeter resolution 3D optical imaging of living tissue using Laminar Optical Tomography", Laser & Photonics Reviews, 3 (1-2), 159-180, (2009).• Burgess S. A, Bouchard M. B, Yuan B, Hillman E. M. C. "Simultaneous Multi-Wavelength Laminar Optical Tomography", Optics Letters, 33 (22), 2710-2712, (2008).• Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media" Optics Letters, 29, (14), 1650-1652 (2004).

*Web Links: Patent Pending: WO/2009/005748

Country/Region: USA

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