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Stem cell growth, cancer treatment and brain tumor detection via transcription factor ATF5

Technology Benefits: * Involves regulating or modulating a single protein, ATF5.* ATF5 is present in many types of tumors; related treatments are widely applicable.* Monitoring ATF5 throughout cancer treatment gives timely feedback on treatment methods.Patent information:Patent Issued (US 8,158,420)

Technology Application: * Cancer diagnostic aid for tumor detection.* Follow tumor progression and evaluate treatment efficacy.* Track prognosis of tumor patients.* Cancer therapies using ATF5 to induce apoptosis in tumor cells.* Regulate differentiation and proliferation of stem cells or progenitor cells for various applications.* Produce neural cells for research and development in neural tissue using differentiated stem cells or progenitor cells.

Detailed Technology Description: Tech Ventures Reference: IR 1649Transcription factor ATF5, a protein involved in the growth and persistence of stem cells, progenitor cells, and tumor cells, is regulated to control the differentiation, progression, and survival of these ...

*Abstract: None

*Inquiry: Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 1649

*Principal Investigator

*Publications: • Greene, L.A., Lee H.Y., Angelastro, J.M. The transcription factor ATF5: role in neurodevelopment and neural tumors. J Neurochem. Vol. 108, Issue 1; pp. 11-22.

*Web Links: Patent issued: 8,158,420Patent Pending: US 2007/0092495 A1

Country/Region: USA

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