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Transient Delivery of Designer Nuclease Protein Using Viral Vectors For Safer Gene Editing

Detailed Technology Description: This new technology addresses the fundamental issues arising in the emerging biotechnology of gene editing, off-target effects from prolonged treatment. Specifically, this invention improves the CRISP

Countries: Not Available

Application No.: None

*Abstract: This new technology addresses the fundamental issues arising in the emerging biotechnology of gene editing, off-target effects from prolonged treatment. Specifically, this invention improves the CRISPR gene editing system by delivering its nuclease component Cas9 by using a traditional gene therapy method utilizing AAV. Once nuclease Cas9 is delivered, the Cas9 will slowly degrade and yield a reduction in genotoxicity and undesirable off-target genome editing associated with CRISPR therapy.

*IP Issue Date: None

*IP Type: Other Patent

Country/Region: USA

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