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Method and System that Simplifies Sample Prep and Pretreatment for Mass Spectrometer Analysis

Summary: Researchers at Purdue University have developed a new approach for liquid-solid phase-liquid extractions and provides systems and methods that allow for the combination of sample preparation and pretreatment with the ionization process. Using a thin capillary tube and coating the inner surface with layers of adsorbents, it is possible to maintain full control of the extraction process. The thin capillary tube allows for the quantitative analysis of small sample amounts. In addition, the extraction capillary can serve as an ionization probe, allowing for the extraction, treatment, and analysis by mass spectrometry without separate sample preparation or pretreatment of a target analyte in a sample.

Technology Benefits: Small sample size Combines sample preparation and pretreatment with the ionization process Better ionization of samples

Technology Application: Mass spectrometry Chemical analysis

Detailed Technology Description: Zheng OuyangOuyang Research GroupPurdue Biomedical Engineering

Countries: United States

Application No.: None

*Abstract

*Background: Mass spectrometry is a powerful tool for the analysis of complex mixtures, which provides specific molecular information based on the molecular weights and chemical structures of the target compounds. Current mass spectrometry techniques require the sample to undergo a time-consuming pretreatment and extraction before it can be analyzed with a mass spectrometer. Once the sample has been treated and extracted it must be ionized, allowing for the manipulation and identification of the sample by the mass spectrometer. Each of these steps requires a significant amount of time and any mistakes could invalidate the entire test.

*IP Issue Date: None

*IP Type: Provisional

*Stage of Development: Process validation in lab

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipZheng OuyangOuyang Research GroupPurdue Biomedical Engineering

Country/Region: USA

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