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Sepsis Treatment Inactivates Endotoxins Using Molecules Derived From Chitosan Derivative

Summary: Purdue University researchers have developed a novel treatment for septicemia involving molecules derived from chitosan. Chitosan is a linear carbohydrate with many commercial and biomedical uses. This treatment inactivates endotoxins, which are toxins associated with certain types of bacteria and stimulates cytokine release (part of the body's inflammatory response that causes swelling and high fever). This new chitosan shows many advantages over current IV treatments for septicemia. This technology can be used to filter endotoxins out of plasmid DNA samples and filter bacteria from water, making contaminated water samples safe to drink.

Technology Benefits: Stronger affinity for inactivating endotoxinsExcellent biocompatibility upon injection Lower potential to cause hemolysis, complement activation, and inflammatory responsesCan filter endotoxins out of plasmid DNA samples and remove bacteria from water

Technology Application: Medical/HealthSepsis treatmentContaminant removal from drinking water

Detailed Technology Description: Yoon YeoYeo LabPurdue Industrial and Physical Pharmacy

Countries: United States

Application No.: None

*Abstract

*Background: Septicemia refers to the presence of pathogens in the bloodstream that leads to sepsis, a potentially life-threatening medical condition characterized by whole-body inflammation and the presence of infection. When microbes infect the blood, skin, lungs or other tissues, the body's immune system generates an inflammatory response in an attempt to fight the infection. The body's immune response to the infection causes the characteristic symptoms of sepsis and can lead to organ failure. The current treatment for sepsis requires antibiotics, fluid drainage, blood transfusions, and dialysis. Since individual cases are caused by different microbes, the correct antibiotic must be chosen to treat the infection. This causes a delay in treatment, which leads to an increase in the mortality rate.

*IP Issue Date: None

*IP Type: Utility

*Stage of Development: Proof of Concept

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipYoon YeoYeo LabPurdue Industrial and Physical Pharmacy

Country/Region: USA

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