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Morphologically Friendly Tissue Imaging

Summary: Researchers at Purdue University have developed a novel, morphologically friendly method for DESI-MS tissue imaging. The use of processing chemicals that preserve native tissue structures, instead of destroying them, expands the applications of DESI-MS to tissue imaging. DESI-MS has been used in real time to help surgeons decide how much tissue to take during cancer removal procedures. This new morphologically friendly procedure allows a facile means to distinguish between cancerous and healthy tissues.

Technology Benefits: Native tissue structure preservedEnhanced imaging of complex cancerous tissues

Technology Application: Medical ImagingPharmaceuticalsMedical/Healthcare

Detailed Technology Description: R. Graham CooksPurdue Biomedical EngineeringAston Labs

Countries: United States

Application No.: None

*Abstract

*Background: Imaging mass spectrometry is currently in the translational phase as a tool in medical histopathology and offers a capability of mapping drugs, metabolites, lipids, peptides, and proteins without the need for labeling. Currently, a primary limitation preventing good correlational analysis is the use of chemicals that destroy native tissue structures.

*IP Issue Date: None

*IP Type: Cont-in-Part

*Stage of Development: Process Validation in Lab

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipR. Graham CooksPurdue Biomedical EngineeringAston Labs

Country/Region: USA

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