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Targeted Contrast Agents for Magnetic Resonance Imaging of Steroid Hormone-Related Diseases

Technology Benefits: Non-invasive Enables targeted imaging Enables spatial and temporal imaging

Detailed Technology Description: Cell-permeable steroid hormone-targeted magnetic resonance imaging contrast agents. #healthcare #mri #imaging

*Abstract: Northwestern researchers have synthesized Gd(III)-chelated steroids that target steroid hormone receptors, including progesterone, estrogen and androgen receptors. The compositions provide novel contrast agents for MRI diagnosis. The water soluble complexes are cell-permeable and label cells and tissues expressing the targeted receptor at lower in vitro and in vivo toxicity than the more hydrophobic ProGlo MRI agent. Receptor status can be used to diagnose, non-invasively, prevalent diseases, such as breast, ovarian, endometrial and prostate cancers, as well as a measure of receptor-positive or -negative status to determine the best course of treatment.

*Inventors: Teresa Woodruff Thomas Meade Preeti Sukerkar Jiyoun Lee

*Publications: Chem Biol. 2007; 14(7):824-34 Bioconjugate Chem. 2011; 22: 2304–2316

Country/Region: USA

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