AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Clock Gene and Gene Product

Technology Benefits
Specific targeting of circadian phenotypes
Detailed Technology Description
Genetic Control of Mammalian Circadian Rhythms: Sequence, Function, and Utility of the Clock Gene and its Product.#circadianrhythm #researchtool #gene
*Abstract

Northwestern researchers have discovered a gene in mice and humans that regulates both the periodicity and the persistence of circadian rhythms. The circadian clock regulates a daily cycle of physical and chemical processes in all eukaryotes and most prokaryotes. This cycle is known to be genetically controlled and to involve periodic macromolecular synthesis, but the elements responsible for circadian rhythmicity in mammals have previously been unknown. Pharmaceutical manipulation of CLOCK expression or activity is expected to alter the level and the timing of the transcription of mper 1 and probably of other genes, thereby altering the circadian cycle. Furthermore, the Clock gene and its product can be used to identify other proteins that control the function of CLOCK and genes that respond to its activity as a transcription factor. Other pathways known to influence circadian rhythm, such as neurotransmitters, hormones, second messengers, and immediate early genes, have diverse, non-specific functions and act throughout the body. However, mutations of the Clock gene which have severe consequences on circadian phenotypes have no other discernible effect on the metabolism or behavior of the organism indicating that clock and its partners can be specifically targeted for using pharmacological approaches for regulating circadian rhythms in mammals.

*Inventors
Joseph S. Takahashi Fred W. Turek Lawrence H Pinto
*Publications
Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 264: 719-25.
Country/Region
USA

For more information, please click Here
Mobile Device