Model for Urinary Bladder Regeneration Utilizing Adult Stem Cells
- Technology Benefits
- Functional vascularization Successful in vivo animal model
- Detailed Technology Description
- A non-human primate model for regenerating the bladder using adult stem cells.#therapeutics #stemcells
- *Abstract
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Northwestern researchers have developed a model for bladder regeneration using bone marrow stem and progenitor cells (BMSPCs). BMSPCs are non-exclusively comprised of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), both of which can be isolated from patients in a simple manner using cell surface markers and subsequently stimulated and expanded to large numbers using cytokines. This process leads to a terminal differentiation program in which these cells form functional vasculature, which addresses a fundamental problem with current regenerating bladder tissue. BM EPCs have been demonstrated in vivo to form functional vasculature that nourishes developing tissue. Furthermore, this technology also demonstrates the ability of a cell mixture of MSCs and/or EPCs in a thin-film scaffold to achieve enhanced tissue repair in an animal model of a damaged bladder.
- *Inventors
- Earl Cheng Natalie Fuller Derek Matoka Arun Sharma Matthew Bury Andrew Marks
- Country/Region
- USA
